Education International Africa Region is made up of 119 Affiliates in 53 of the 57 countries in Africa, including Lebanon and Palestine in the Middle East. Several countries have multiple education sector unions making unity among and within unions a major concern for the region. The regional office is preoccupied with helping affiliates to develop stronger unions and encouraging them to form united fronts.

English, French, Portuguese, and Arabic are the major official languages owing to the colonial and religious influence. There are numerous indigenous languages within the countries although a few are spoken across several countries. The region therefore must contend with varied languages and cultures.

The region is also involved in professional development programmes, promotion of early childhood education, women in education empowerment, the fight against child labour, and responding to the growing commercialisation and privatisation of education.